|(6S,7S,13aR)-1,2,3,13-四甲氧基-6,7-二甲基-5,6,7,8-四氢苯并[3',4 ']环辛烷并[1',2':4,5]苯并[1,2-d][1,3]二氧杂环戊烷-6-醇|CsnPharm

CAS No.: 58546-54-6

五味子醇乙 Catalog No. CSN11112

Synonyms: Gomisin-A;TJN-101;Wuweizi alcohol-B

Gomisin A is a major dibenzocyclooctadiene lignan from medicinal plant Schizandra Chinese, exhibiting hepatoprotective, antiviral, anticancer, neuroprotective and anti-inflammatory activity.

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Gomisin A from the fruit of Schisandra chinensis has many pharmacological properties, including hepato-protective, anti-diabetic, and anti-oxidative stress. Gomisin A inhibited reactive oxygen species production even in the SIPS-HDF (stress-induced premature senescence-human diploid fibroblast) cells. Gomisin A was also able to attenuate the activity of senescence-associated β-galactosidase and the production of pro-inflammatory molecules in the SIPS as well as aged HDF cells. In addition, gomisin A promoted the autophagy and mitochondrial biogenesis factors through the translocation of nuclear factor erythroid 2-related factor-2, and inhibited aging progression in the SIPS-HDF cells^[3]. Using human liver microsomes, a reversible inhibition assay revealed that Gom A ( Gomisin A) was a competitive inhibitor with a KI value of 1.10 µM, and the time- and NADPH-dependent CYP3A inhibition of Gom A was observed in a time-dependent inhibition assay (KI = 0.35 µM, kinact = 1.96 min-1)^[4]. Both oral and intraperitoneal administration of G.A (50 mg/kg) inhibited lung metastasis of CT26 cells. G.A (Gomisin A) significantly decreased the viability of various CRC (colorectal cancer) cell lines, whereas it did not change the proliferation of normal colon cells. Moreover, the migration and invasion of CRC cells were reduced by G.A treatment. Especially, G.A decreased matrix metalloproteinase (MMP)-2 and MMP-9 expressions and activities^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.4012 mL
- 12.0058 mL
- 24.0117 mL
- 5 mM
- 0.4802 mL
- 2.4012 mL
- 4.8023 mL
- 10 mM
- 0.2401 mL
- 1.2006 mL
- 2.4012 mL

技术信息

CAS号

58546-54-6

储存条件

粉末: Sealed in dry,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C23H28O7

运输

蓝冰

分子量

416.46

别名

Gomisin-A;TJN-101;Wuweizi alcohol-B;Besigomsin;Wuweizichun B;五味子醇乙

溶解度

DMSO	50.0 mg/mL (120.1 mM) warming
Water	Insoluble

动物实验配方

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

五味子醇乙 Catalog No. CSN11112

靶点选择性

请登录您的专属账户

确认信息